May cause salicylism with effects similar to those of skin absorption. Material safety data sheet salicylic acid valid for. Identification product name salicylic acid usp cat no. Wear appropriate protective eyeglasses or chemical safety goggles as described by oshas eye and face protection regulations in 29 cfr 1910.
Salicylic acid allows cells of the epidermis to more readily slough off. A275250lb casno 69727 synonyms 2hydroxybenzoic acid recommended use laboratory chemicals. Salicylic acid is lipophilic and has the ability to penetrate into oilfilled follicles and breakdown impaction. Buy trisalicylic acid cas 85531175, a biochemical for proteomics research, from santa cruz. Chemical product and company identification product name. Slightly hazardous in case of skin contact permeator. The melting properties of salicylic acid were determined by differential scanning calorimetry. Plasma concentrations of aspirin following after administration of the extendedrelease form are mostly undetectable 48 hours after ingestion of a single dose. The koc of salicylic acid is estimated as 404src, using a log kow of 2. Salicylic acid, when taken orally, is also an analgesic and an antiinflammatory.
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Salicylic acid is a colorless crystalline acid derived from organic sources. Page 1 of 8 msds phosphoric acid, 85% material safety data sheet msds phosphoric acid, 85% 1. Salicylic acid 69727 100 toxicological data on ingredients. Jun 07, 2019 salicylic acid is a potent skincare ingredient, but how does it work. Dailymed duofilm wart remover salicylic acid liquid. Our msds database is an easy to use, do it yourself tool, and best of all. This chemical has a variety of applications and can present several health hazards if used without adequate precautions. If the theoretical andc percent yieldbrief will be 100% helmenstine, 2018. Salicylic acid usp revision date 25jun2019 salicylic acid 891 mgkg rat 2 gkg rat 0.
Seek medical attention if irritation, discomfort, or vomiting persists. Hazard identification hazardous in case of skin contact irritant, of eye contact irritant, of ingestion, of inhalation lung irritant. Methyl salicylate is fully degradation biodegradable. The only beta hydroxy acid typically used in skin care is salicylic acid. Salicylic acid none listed none listed none listed osha vacated pels. Radchem cc po box 166982 brackendowns alberton 1454 telephone. Most important symptoms and effects, both acute and.
Acetylsalicylic acid is hydrolyzed in the plasma to salicylic acid. Salicylic acid is a monohydroxybenzoic acid that is benzoic acid with a hydroxy group at the ortho position. Material safety data sheet page 1 of 2 salicylic acid. Betamethasone salicylic acid ointment formulation msds. Call a poison center or doctorphysician if you feel unwell specific treatment see supplemental first aid instructions on this label rinse mouth. Material safety data sheet salicylic acid section 1 chemical product and company identification msds name. In case of contact, immediately wash with plenty of soap and water for at least 5 minutes. A correlation was observed between the solubility and the vant hoff enthalpy of solution. Acetic anhydride safety data sheet according to the federal final rule of hazard communication revised on 2012 hazcom 2012 5. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Weve included the most sought after safety data sheets, and the database just keeps growing. If available, please refer to the product information sheet for application and handling instructions.
Salicylic acid revision 1 revision date 0804 2015 12. Salicylic acid is also a comedolytic medication because it can break up comedones and open clogged pores. California, new jersey, pennsylvania, minnesota, massachusetts. They react in this way with all bases, both organic for example, the amines and inorganic. More than 200,000 customers have access to over 2,500 highquality pharmaceutical raw materials. Never provide drink or induce vomiting in the event of loss of consciousness. Salicylic acid msds rphrases r22 harmful if swallowed. Salicylic acid acylbdglucuronide methods for cleaning up wear protective clothing as described in section 8 of this safety data sheet.
Carboxylic acids donate hydrogen ions if a base is present to accept them. Salicylic acid revision 1 revision date 08042015 12. Physical and chemical properties molecular formula 2hoc6h4cooh. This chemical is considered hazardous by the 2012 osha hazard. Laboratory experiments have resulted in mutagenic effects. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. M21127 section i product and company identification msds name. Salicylic acid which is a naturally occurring substance found in many plants can be acetylated using acetic anhydride, yielding aspirin and acetic acid as a byproduct. Severe salicylate intoxication may cause central nervous system disturbances such as convulsions and coma, skin eruptions, and alteration in the acidbase balance. Product and company identification product name as on label. Safety data sheet creation date 24nov2009 revision date 25jun2019 revision number 6 1. Use water spray or fog for cooling exposed containers. Sigmaaldrich 3050 spruce street saint louis mo 63103 usa telephone.
Prevent firefighting water from entering environment. Search results for salicylic acid msds at sigmaaldrich. Jul 08, 2015 salicylic acid is a colorless crystalline acid derived from organic sources. Salicylic acid is a key ingredient in many skincare products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. In addition to serving as an important active metabolite of aspirin. Causes irritation of the mucous membrane and upper respiratory tract. Preparation of salicylic acid salicylic acid will be prepared by a basepromoted hydrolysis, or saponi. It is obtained from the bark of the white willow and wintergreen leaves.
Uses advised against food, drug, pesticide or biocidal product use details of the supplier of the safety data sheet 2. The product itself and its products of degradation are not toxic. It also functions to normalize the excess interfollicular cell shedding that contributes to the formation of microcomedones. Relevant identified uses of the substance or mixture and uses advised against identified uses laboratory reagent. The product will be analyzed by melting point analysis and carbon nmr. Collect powder using special dust vacuum cleaner with particle filter or carefully sweep into suitable waste disposal containers and seal securely. Clear up spills immediately and dispose of waste safely. State of the art ingredients fast friendly service msds material safety data sheet 512 5352711 unusual fire and explosion hazards. What does salicylic acid do for your skin, exactly. Aluminum chloride solutions 20% in sda, 400523, 400763.
Material safety data sheet salicylic acid msds section 1. Hazards identification potential acute health effects. Preparation of salicylic acid santa monica college. Containers of this material may be hazardous when empty, as they retain product residues.
Uses advised against food, drug, pesticide or biocidal product use details of the supplier of the safety data. Emergency telephone no 8668670110 5909 sea lion place, suite h carlsbad, ca 92010 7604483600 section 1. Lowviscosity, slightly yellowlight brown liquid with solventlike odor. Material safety data sheet msds phosphoric acid, 85%. Skin contact in case of skin irritation, discontinue use of product. Salicylic acid blocks the production of certain hormones called prostaglandins that are released from damaged cells. Remove contact lenses, if applicable, and continue flushing.
Whether or not acetaylsalicylic acid aspirin is a human teratogen is controversial. According to a classification scheme3, this estimated koc value suggests that salicylic acid is expected to have moderate mobility in soil. Safety data sheet northwest missouri state university. Salicylic acidacylbdglucuronide methods for cleaning up wear protective clothing as described in section 8 of this safety data sheet. Ac158180000, ac158180500, ac158185000, ac385760000 synonyms. It is a common experiment performed in organic chemistry labs, and generally tends to produce low yields due to the relative difficulty of its extraction from an aqueous state.
Salicylic acid causes shedding of the outer layer of skin. Aluminum chloride solutions 40% in 70% sda, 400597. Were breaking down how salicylic acid works on the skin, what types of acne it does and doesnt work on, and how best to. Safety data sheet according to 29cfr19101200 and ghs rev. California prop 65 the following statement s is are made in order to comply with the california safe drinking water act. Hold eyelids open and flush with a steady, gentle stream of water for at least 15 minutes. Salicylic acid from latin salix, willow tree is a lipophilic monohydroxybenzoic acid, a type of phenolic acid, and a beta hydroxy acid bha.
Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. It has a role as an antiinfective agent, an antifungal agent, a keratolytic drug, an ec 1. Here are some important safety tips to keep in mind when handling and storing salicylic acid. Product and company identification salicylic acid synonymsgeneral names. Matching the most optimal personalized medication with the patients needs is the essence of compounding. Salicylic acid was measured at 24 hours following a single dose of extendedrelease acetylsalicylic acid f4405. This colorless crystalline organic acid is widely used in organic synthesis and functions as a plant hormone. Duofilm wart remover salicylic acid liquid out of scope out of scope for rxnorm and will not receive rxnorm normal forms. Composition and information on ingredients composition. It is mainly used in the pharmaceutical industry for the manufacture of antipyretic, analgesic, antiinflammatory and diuretic drugs. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database.
Bluing reagent methanol bluing reagent scotts substitute chlorazol black e. Hazardous in case of skin contact irritant, of eye contact irritant, of ingestion, of inhalation lung irritant. Sphrases s26 in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Salicylic acid is used as a food preservative as well as in the treatment of many skin disorders such as acne, dandruff, psoriasis and seborrheic dermatitis of the skin and scalp. If in scope, these drugs will include rxnorm normal forms when editing is complete. A benzoate ester obtained by the formal condensation of carboxy group of salicylic acid with one of the hydroxy groups of ethylene glycol 2hydroxyethyl salicylate preparation products and raw materials raw materials preparation products 2hydroxyethyl. Contains the following potentially hazardous materials. Your new online msds binder is a place for you to store the material safety data. Identification of the substancepreparation and of the company or firm 1. Solubility and melting properties of salicylic acid request pdf. Salicylic acid topical for the skin is used in the treatment of acne, dandruff, seborrhea, or psoriasis, and to remove corns, calluses, and warts there are many brands and forms of salicylic acid. Material safety data sheet acetylsalicylic acid product observe all federal, state, and local environmental regulations. Their reactions with bases, called neutralizations, are accompanied by the evolution of substantial amounts of heat. Enter synonyms, trade names or additional information found in section 1.703 1043 900 86 958 699 1400 807 911 179 337 237 1500 626 1232 101 1117 1137 757 743 808 764 647 762 833 251 1150 10 10 135 454 393 1391 48 1001